Staphylococcus aureus Mutant Screen Reveals Interaction of the Human Antimicrobial Peptide Dermcidin with Membrane Phospholipids
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چکیده
منابع مشابه
Staphylococcus aureus mutant screen reveals interaction of the human antimicrobial peptide dermcidin with membrane phospholipids.
Antimicrobial peptides (AMPs) form an important part of the innate host defense. In contrast to most AMPs, human dermcidin has an anionic net charge. To investigate whether bacteria have developed specific mechanisms of resistance to dermcidin, we screened for mutants of the leading human pathogen, Staphylococcus aureus, with altered resistance to dermcidin. To that end, we constructed a plasmi...
متن کاملDermcidin-α: Green Variant of Dermcidin, Human Antimicrobial Peptide in Sweat†
10.1021/bi0160516 CCC: $22.00 © 2002 American Chemical Society Published on Web 04/01/2002 ABSTRACT: Dermcidin (DCD), an recently discovered antimicrobial peptide, plays a role in the innate response by regulating human skin flora in sweat. Here we describe the isolation of the gene of a variant of dermcidin, designated as DCD-α. This variant has 75% homology to dermcidin and has been found in ...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2009
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.00428-09